NSC 350625
TIC10
CAS: 1616632-77-9
Molecular Formula: C24H26N4O
NSC 350625 - Names and Identifiers
NSC 350625 - Physico-chemical Properties
| Molecular Formula | C24H26N4O |
| Molar Mass | 386.49 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Boling Point | 559.7±60.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Color | Pale yellow |
| pKa | 6.38±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| In vitro study | TIC10 causes a dose-dependent increase in TRAIL mRNA and induces the TRAIL protein to localize on the cell surface of several cancer cell lines in a p53-independent manner. In vitro, TIC10 has broad-spectrum activity against multiple malignancies and induces an increase in the sub-G1 DNA content that predicts cell death in TRAIL-sensitive HCT116 p53 −/− cells, however, the cell cycle composition of normal fibroblasts was not altered at the equivalent dose. TIC10 reduces clonal survival of cancer cell lines and reserves normal fibroblasts. TIC10 increases the percentage of sub-G1 DNA in cancer cells in a p53-independent and Bax-dependent manner, as previously reported for TRAIL-mediated apoptosis. Tic10-induced upregulation of TRAIL is Foxo3a dependent, which also upregulates TRAIL death receptor DR5 in other targets, probably due to sensitization of some TRAIL-resistant tumor cells. TIC10 inactivates the kinase Akt and extracellular signal-regulated kinase (ERK), causing Foxo3a to migrate to the nucleus and then bind to the TRAIL promoter to regulate gene transcription. TIC10 is a potent anti-tumor therapeutic agent that acts on tumor cells and their microenvironment to increase the concentration of the endogenous tumor suppressor gene TRAIL. |
| In vivo study | TIC10 and TRAIL were administered in multiple doses, while the HCT116 p53 |
NSC 350625 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.587 ml | 12.937 ml | 25.874 ml |
| 5 mM | 0.517 ml | 2.587 ml | 5.175 ml |
| 10 mM | 0.259 ml | 1.294 ml | 2.587 ml |
| 5 mM | 0.052 ml | 0.259 ml | 0.517 ml |
Last Update：2024-01-02 23:10:35
NSC 350625 - Introduction
TIC10 is a chemical substance, all called TRAIL-induction compound 10, is a compound with anti-cancer activity.
Nature:
TIC10 is a white to light yellow solid, stable at room temperature and pressure. It is a low-toxic compound that is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO) and ethanol.
Use:
TIC10 is an anti-tumor drug with the ability to induce apoptosis of tumor cells. It inhibits tumor growth by activating the human tumor necrosis factor-related apoptosis-inducing receptor (TRAIL) signaling pathway. TIC10 has been shown in animal models to have therapeutic effects on a variety of cancer types, such as breast cancer, lung cancer, colorectal cancer, etc.
Preparation Method:
Regarding the preparation method of TIC10, a common method is through chemical synthesis. Specifically, it can be obtained by the reaction of the synthetic amino acid glycine and a chemical reagent such as thionyl chloride. The specific preparation conditions need further experimental operation.
Safety Information:
TIC10 shows some toxicity at high doses. When using TIC10, strict safety practices need to be followed, including wearing appropriate personal protective equipment, avoiding contact with skin and inhalation, and keeping the experimental environment well ventilated. In addition, attention needs to be paid to the storage and handling of the compound, avoiding ignition sources and conditions that cause explosions. For specific safety guidelines and details, it is recommended to consult the safety data sheet (SDS) of the relevant chemical or consult the relevant professional before use.
Nature:
TIC10 is a white to light yellow solid, stable at room temperature and pressure. It is a low-toxic compound that is soluble in some organic solvents, such as dimethyl sulfoxide (DMSO) and ethanol.
Use:
TIC10 is an anti-tumor drug with the ability to induce apoptosis of tumor cells. It inhibits tumor growth by activating the human tumor necrosis factor-related apoptosis-inducing receptor (TRAIL) signaling pathway. TIC10 has been shown in animal models to have therapeutic effects on a variety of cancer types, such as breast cancer, lung cancer, colorectal cancer, etc.
Preparation Method:
Regarding the preparation method of TIC10, a common method is through chemical synthesis. Specifically, it can be obtained by the reaction of the synthetic amino acid glycine and a chemical reagent such as thionyl chloride. The specific preparation conditions need further experimental operation.
Safety Information:
TIC10 shows some toxicity at high doses. When using TIC10, strict safety practices need to be followed, including wearing appropriate personal protective equipment, avoiding contact with skin and inhalation, and keeping the experimental environment well ventilated. In addition, attention needs to be paid to the storage and handling of the compound, avoiding ignition sources and conditions that cause explosions. For specific safety guidelines and details, it is recommended to consult the safety data sheet (SDS) of the relevant chemical or consult the relevant professional before use.
Last Update：2024-04-09 21:54:55
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Product Name: TIC10 Visit Supplier Webpage Request for quotationCAS: 1616632-77-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: TIC10 Visit Supplier Webpage Request for quotationCAS: 1616632-77-9
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: TIC10 Request for quotationCAS: 1616632-77-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: TIC10 Visit Supplier Webpage Request for quotationCAS: 1616632-77-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: TIC10 Visit Supplier Webpage Request for quotationCAS: 1616632-77-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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